Carlyle answered with five runs in the bottom of the fifth inning after Central scored four runs in the top of the inning as the Indians edged the Cougars 5-4 on Saturday in the championship game of the Class 2A Carlyle Regional.
Breanna Smith had a two-run single to highlight the rally for the Indians (15-10), who advance to play Shelbyville (17-8) and hard-throwing pitcher Grace Moll at 4 p.m. Wednesday in the Teutopolis Sectional.
It was the first regional title for the Indians since 2002.
Carlyle pitcher Paige Rakers ended up with a three-hitter. She allowed one earned run, while striking out six and walking none.
The Cougars end their season at 14-11.
Madison Schmitz homered and drove in four runs and Ali Ringering went 4-for-4 as the Red Bud Musketeers put on an offensive display in beating the Gibault Hawks 10-1 in the championship game of the Class 2A Trico Regional.
The Musketeers scored six runs in the first inning and never looked back.
Both Lauren Horrell and Cassidy Melliere also had two hits for the Musketeers, who banged out 13 hits in the game.
Red Bud pitcher Becca Vogt allowed six hits, while striking out four and walking three.
The Musketeers (21-4) advance to play unbeaten Massac County (29-0) at 4:30 p.m. Wednesday in the Du Quoin Sectional.
The Hawks finished their season with a 19-14 record.
Kiley Pelker and Abby Liske both homered as the defending state champion Nashville Hornettes rolled past the Du Quoin Indians 10-2 in the title game of the Pinckneyville Regional.
Pelker had a solo homer in the third inning and Liske had a three-run homer in the sixth.
"We can't do much better than that offensively,'' Nashville coach Dempsey Witte said. "We pounded out 12 hits and we threatened in every inning except one.''
Nashville pitcher Maci Ingram gave up only two hits. Both were solo homers by Cassidy Rice.
On Rice's second homer in the sixth inning, Nashville center fielder Nicole Deering flipped over the fence as she caught the ball. Deering dropped the ball as she landed on her head and shoulder, and she was taken by ambulance to the hospital.
"She's OK,'' Witte said. "I think she'll be able to play in our next ballgame.''
The Hornettes (34-4) will play West Frankfort at 4:30 p.m. Tuesday in the Du Quoin Sectional.
Class 1A Metro-East Lutheran Regional
Maddie Baalman struck out 16 on her way to a one-hitter as Hardin Calhoun beat Metro-East Lutheran 10-0 in the championship game of the Class 1A Metro-East Lutheran Regional.
The Knights ended their season with an 8-16 record.