Two lanes will be closed on the eastbound lanes of Interstate 255 across the Jefferson Barracks Bridge beginning at 7 p.m. Friday, according to the Missouri Department of Transportation.
The closures will allow crews to replace bridge joints.
Lanes will reopen by 5 a.m. Monday.
All westbound lanes will remain open.
MoDOT recommends that drivers leaving St. Louis to head into Illinois should consider using the Poplar Street Bridge or the Martin Luther King Bridge.