Fire crews are on scene at a house in the 2000 block of Dorris Avenue.
Dupo, Cahokia, and Prairie Du Pont fire crews responded to the fire. Ameren Illinois and police are also on scene.
Cahokia Fire Chief Stepehn Robbins said no one was in the house and there were no injuries. He said crews were unable to enter the structure, which they believe was used for storage.